An organocatalytic route to 2-heteroarylmethylene decorated N-arylpyrroles

Abstract

A concise and regioselective preparation of 2-heteroarylmethylene decorated N-arylpyrroles is described through a metal-free Mannich/Wittig/hydroamination sequence followed by isomerization of the N-arylpyrrolidine adducts. Furthermore, the C–H regioselective oxidation of these substrates is demonstrated, extending the molecular diversity and versatility of these scaffolds.

Keywords

• C–H oxidation
• isomerization
• N-arylpyrrole
• organocatalysis