Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment

Andrew E. Massey; Shabnam Malik; Mohammad Sikander; Kyle A. Doxtater; Manish K. Tripathi; Sheema Khan; Murali M. Yallapu; Meena Jaggi; Subhash C. Chauhan; Bilal B. Hafeez

doi:10.3390/ijms22105278

International Journal of Molecular Sciences (May 2021)

Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment

Andrew E. Massey,
Shabnam Malik,
Mohammad Sikander,
Kyle A. Doxtater,
Manish K. Tripathi,
Sheema Khan,
Murali M. Yallapu,
Meena Jaggi,
Subhash C. Chauhan,
Bilal B. Hafeez

Affiliations

Andrew E. Massey: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, USA
Shabnam Malik: Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA
Mohammad Sikander: Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA
Kyle A. Doxtater: Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA
Manish K. Tripathi: Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA
Sheema Khan: Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA
Murali M. Yallapu: Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA
Meena Jaggi: Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA
Subhash C. Chauhan: Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA
Bilal B. Hafeez: Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA

DOI: https://doi.org/10.3390/ijms22105278
Journal volume & issue: Vol. 22, no. 10
p. 5278

Abstract

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Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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Abstract

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