Infrared Spectroscopy for the Quality Control of a Granular Tebuthiuron Formulation

Abstract

Tebuthiuron is a selective herbicide for woody species and is commonly manufactured and sold as a granular formulation. This project investigated the use of infrared spectroscopy for the quality analysis of tebuthiuron granules, specifically the prediction of moisture content and tebuthiuron content. A comparison of different methods showed that near-infrared spectroscopy showed better results than mid-infrared spectroscopy, while a handheld NIR instrument (MicroNIR) showed slightly improved results over a benchtop NIR instrument (Antaris II FT-NIR Analyzer). The best-performing models gave an R2CV of 0.92 and RMSECV of 0.83% w/w for moisture content, and R2CV of 0.50 and RMSECV of 7.5 mg/g for tebuthiuron content. This analytical technique could be used to optimise the manufacturing process and reduce the costs of post-manufacturing quality assurance.

Keywords

• process analytical technology
• quality assurance
• non-destructive assessment
• NIRS