Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling

Janos Paloczi, PhD; Csaba Matyas, MD, PhD; Resat Cinar, PhD; Zoltan V. Varga, MD, PhD; György Hasko, MD, PhD; Thomas H. Schindler, MD; George Kunos, MD, PhD; Pal Pacher, MD, PhD

JACC: Basic to Translational Science (Sep 2019)

Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling

Janos Paloczi, PhD,
Csaba Matyas, MD, PhD,
Resat Cinar, PhD,
Zoltan V. Varga, MD, PhD,
György Hasko, MD, PhD,
Thomas H. Schindler, MD,
George Kunos, MD, PhD,
Pal Pacher, MD, PhD

Affiliations

Janos Paloczi, PhD: Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland
Csaba Matyas, MD, PhD: Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland
Resat Cinar, PhD: Laboratory of Physiological Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland
Zoltan V. Varga, MD, PhD: Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland
György Hasko, MD, PhD: Department of Anesthesiology, Columbia University, New York, New York
Thomas H. Schindler, MD: Division of Nuclear Medicine, Washington University in St. Louis, St. Louis, Missouri
George Kunos, MD, PhD: Laboratory of Physiological Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland
Pal Pacher, MD, PhD: Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland; Address for correspondence: Dr. Pal Pacher, Laboratory of Cardiovascular Physiology and Tissue Injury, 5625 Fishers Lane, Room 2N-17, Bethesda, Maryland 20892-9413.

Journal volume & issue: Vol. 4, no. 5
pp. 625 – 637

Abstract

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Summary: Excessive binge alcohol drinking may adversely affect cardiovascular function. In this study we characterize the detailed hemodynamic effects of an acute alcohol binge in mice using multiple approaches and investigate the role of the endocannabinoid–cannabinoid 1 receptor (CB1-R) signaling in these effects. Acute alcohol binge was associated with elevated levels of cardiac endocannabinoid anandamide and profound cardiovascular dysfunction lasting for several hours and redistribution of circulation. These changes were attenuated by CB1-R antagonist or in CB1-R knockout mice. Our results suggest that a single alcohol binge has profound effects on the cardiovascular system, which involve endocannabinoid–CB1-R signaling. Key Words: binge alcohol drinking, cannabinoids, contractility, endocannabinoids

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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