Micromachines (Feb 2024)

Using Compound Neural Action Potentials for Functional Validation of a High-Density Intraneural Interface: A Preliminary Study

  • Aritra Kundu,
  • Erin Patrick,
  • Seth Currlin,
  • Ryan Madler,
  • Francisco Delgado,
  • Ahmed Fahmy,
  • Rik Verplancke,
  • Marco Ballini,
  • Dries Braeken,
  • Maaike Op de Beeck,
  • Nima Maghari,
  • Kevin J. Otto,
  • Rizwan Bashirullah

DOI
https://doi.org/10.3390/mi15020280
Journal volume & issue
Vol. 15, no. 2
p. 280

Abstract

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Compound nerve action potentials (CNAPs) were used as a metric to assess the stimulation performance of a novel high-density, transverse, intrafascicular electrode in rat models. We show characteristic CNAPs recorded from distally implanted cuff electrodes. Evaluation of the CNAPs as a function of stimulus current and calculation of recruitment plots were used to obtain a qualitative approximation of the neural interface’s placement and orientation inside the nerve. This method avoids elaborate surgeries required for the implantation of EMG electrodes and thus minimizes surgical complications and may accelerate the healing process of the implanted subject.

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