Skin-like breathable wound dressings with antimicrobial and hemostatic properties
Hanbai Wu,
Chuanwei Zhi,
Yuhan Chen,
Xiong Zhou,
Cong Wang,
Raymond H.W. Lam,
Tingwu Qin,
Guibing Fu,
Zhu Xiong,
Kaisong Huang,
Jia-Horng Lin,
Shuo Shi,
Jinlian Hu
Affiliations
Hanbai Wu
Department of Biomedical Engineering, City University of Hong Kong 999077, Hong Kong
Chuanwei Zhi
Department of Biomedical Engineering, City University of Hong Kong 999077, Hong Kong
Yuhan Chen
Department of Biomedical Engineering, City University of Hong Kong 999077, Hong Kong
Xiong Zhou
Department of Biomedical Engineering, City University of Hong Kong 999077, Hong Kong
Cong Wang
Department of Biomedical Engineering, City University of Hong Kong 999077, Hong Kong
Raymond H.W. Lam
Department of Biomedical Engineering, City University of Hong Kong 999077, Hong Kong; City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, PR China
Tingwu Qin
Institute of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China
Guibing Fu
Department of Pediatric Orthopedics, Shenzhen Children's Hospital, Shenzhen 518034, Guangdong Province, PR China
Zhu Xiong
Department of Pediatric Orthopedics, Shenzhen Children's Hospital, Shenzhen 518034, Guangdong Province, PR China
Kaisong Huang
Department of Biomedical Engineering, City University of Hong Kong 999077, Hong Kong
Jia-Horng Lin
Innovation Platform of Intelligent and Energy-Saving Textiles, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, PR China; Laboratory of Fiber Application and Manufacturing, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407802, Taiwan
Shuo Shi
Department of Biomedical Engineering, City University of Hong Kong 999077, Hong Kong
Jinlian Hu
Department of Biomedical Engineering, City University of Hong Kong 999077, Hong Kong; City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, PR China; Correspondence author.
Wound healing requires a contamination-free, sterile, and breathable environment. However, to develop an ideal wound dressing with all these functionalities simultaneously poses significant challenges. In this study, we designed a wound dressing that mimics the structure of skin with good breathability and protective functions. The wound dressing consists of a hydrophilic Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) membrane coated with zinc oxide nanoparticles and a hydrophobic polyvinylidene fluoride (PVDF) membrane. Meanwhile, plasma treatment was also utilized to bond the two layers, resulting in an enhancement of 60 % in mechanical properties. The crosslinked fibrous membranes exhibited uniform stress distribution when stretching. Due to the unique structures of the wound dressing, it demonstrates wound exudate management, antibacterial functions, and hemostatic properties. The hydrophobic layer guided wound exudate towards the hydrophilic layer and the zinc oxide nanoparticles acted as a barrier against external bacteria and released zinc ions to inhibit bacterial growth in the exudate. Moreover, the water vapor transmission rate (WVTR) was measured to be over 86.55 kg/m2/day, the hemolysis rate was 2.38 %, and an impressive 81.98 % healing rate was recorded during in vitro wound healing. This skin-mimicking wound dressing shows great potential as a promising solution for the therapy of chronic wounds and infections.
