Nature Communications (Aug 2021)

Structural basis for Ca2+ activation of the heteromeric PKD1L3/PKD2L1 channel

  • Qiang Su,
  • Mengying Chen,
  • Yan Wang,
  • Bin Li,
  • Dan Jing,
  • Xiechao Zhan,
  • Yong Yu,
  • Yigong Shi

DOI
https://doi.org/10.1038/s41467-021-25216-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Hetero-oligomeric TRP-like channels such as PKD1L3/PKD2L1 play crucial roles in a range of physiological and pathophysiological processes. Here, the authors present the cryo-EM structures of a minimal functional murine PKD1L3/PKD2L1 complex in the absence and presence of calcium and further supported through structure-guided mutagenic studies, they discuss the mechanism of calcium-induced channel activation.