Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer

Nil Vanli; Jinghao Sheng; Shuping Li; Zhengping Xu; Guo-Fu Hu

doi:10.1038/s42003-022-03597-1

Communications Biology (Jun 2022)

Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer

Nil Vanli,
Jinghao Sheng,
Shuping Li,
Zhengping Xu,
Guo-Fu Hu

Affiliations

Nil Vanli: Divison of Hematology and Oncology, Department of Medicine, Tufts Medical Center
Jinghao Sheng: Divison of Hematology and Oncology, Department of Medicine, Tufts Medical Center
Shuping Li: Divison of Hematology and Oncology, Department of Medicine, Tufts Medical Center
Zhengping Xu: Institute of Environmental Medicine, Zhejiang University School of Medicine
Guo-Fu Hu: Divison of Hematology and Oncology, Department of Medicine, Tufts Medical Center

DOI: https://doi.org/10.1038/s42003-022-03597-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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RNase 4 is presented as a biomarker for prostate cancer, inducing AXL activation that promotes AKT/S6K activation and tumor cell proliferation, and its inhibition reduces the growth of xenograft human prostate tumors.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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