Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor
Balázs Decsi,
Réka Krammer,
Kristóf Hegedűs,
Ferenc Ender,
Benjámin Gyarmati,
András Szilágyi,
Róbert Tőtős,
Gabriel Katona,
Csaba Paizs,
György T. Balogh,
László Poppe,
Diána Balogh-Weiser
Affiliations
Balázs Decsi
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
Réka Krammer
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
Kristóf Hegedűs
SpinSplit Llc., 1082 Budapest, Leonardo da Vinci u. 43b, Hungary
Ferenc Ender
SpinSplit Llc., 1082 Budapest, Leonardo da Vinci u. 43b, Hungary
Benjámin Gyarmati
Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
András Szilágyi
Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
Róbert Tőtős
Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, Romania
Gabriel Katona
Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, Romania
Csaba Paizs
Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, Romania
György T. Balogh
Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, 1111 Budapest, Budafoki út 8, Hungary
László Poppe
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
Diána Balogh-Weiser
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH2) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip).
