Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load

• Sebastian Vosberg,
• Luise Hartmann,
• Klaus H. Metzeler,
• Nikola P. Konstandin,
• Stephanie Schneider,
• Ashok Varadharajan,
• Andreas Hauser,
• Stefan Krebs,
• Helmut Blum,
• Stefan K. Bohlander,
• Wolfgang Hiddemann,
• Johanna Tischer,
• Karsten Spiekermann,
• Philipp A. Greif

Affiliations

Sebastian Vosberg

Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany;German Cancer Consortium (DKTK), partner site Munich, Germany;German Cancer Research Center (DKFZ), Heidelberg, Germany;Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany

Luise Hartmann

Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany;German Cancer Consortium (DKTK), partner site Munich, Germany;German Cancer Research Center (DKFZ), Heidelberg, Germany;Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany

Klaus H. Metzeler

Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany;German Cancer Consortium (DKTK), partner site Munich, Germany;German Cancer Research Center (DKFZ), Heidelberg, Germany;Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany

Nikola P. Konstandin

Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany

Stephanie Schneider

Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany;Institute of Human Genetics, University Hospital, LMU Munich, Germany

Ashok Varadharajan

Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Germany

Andreas Hauser

Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Germany

Stefan Krebs

Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Germany

Helmut Blum

Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Germany

Stefan K. Bohlander

Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, The University of Auckland, New Zealand

Wolfgang Hiddemann

Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany;German Cancer Consortium (DKTK), partner site Munich, Germany;German Cancer Research Center (DKFZ), Heidelberg, Germany;Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany

Johanna Tischer

Hematopoietic Stem Cell Transplantation, Department of Medicine III, University Hospital, LMU Munich, Germany

Karsten Spiekermann

Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany;German Cancer Consortium (DKTK), partner site Munich, Germany;German Cancer Research Center (DKFZ), Heidelberg, Germany;Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany

Philipp A. Greif

Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany;German Cancer Consortium (DKTK), partner site Munich, Germany;German Cancer Research Center (DKFZ), Heidelberg, Germany;Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany