Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions

Barbara Garita; Jenna Maligro; Saghi Sadoughi; Po Hung Wu; Ellen Liebenberg; Andrew Horvai; Thomas M. Link; Galateia J. Kazakia

Medicine in Novel Technology and Devices (Jun 2021)

Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions

Barbara Garita,
Jenna Maligro,
Saghi Sadoughi,
Po Hung Wu,
Ellen Liebenberg,
Andrew Horvai,
Thomas M. Link,
Galateia J. Kazakia

Affiliations

Barbara Garita: Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA
Jenna Maligro: Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA
Saghi Sadoughi: Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA
Po Hung Wu: Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA
Ellen Liebenberg: Department of Orthopaedic Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA
Andrew Horvai: Department of Pathology, University of California, San Francisco, 1825 4th St, San Francisco, CA, 94143, USA
Thomas M. Link: Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA
Galateia J. Kazakia: Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA; Corresponding author.

Journal volume & issue: Vol. 10
p. 100062

Abstract

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Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes. High resolution peripheral quantitative computed tomography (HR-pQCT) enables in vivo microstructure characterization but is limited in its ability to visualize important biological features. We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility. These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation.

Published in Medicine in Novel Technology and Devices

ISSN: 2590-0935 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Medical technology
Website: https://www.journals.elsevier.com/medicine-in-novel-technology-and-devices

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