ChAd155-RSV vaccine is immunogenic and efficacious against bovine RSV infection-induced disease in young calves

Abstract

A pediatric RSV vaccine is an unmet medical need, even after >50 years of effort. Here, the authors show that a chimpanzee adenovirus based RSV vaccine candidate protects calves from disease upon RSV infection, regardless of the time after vaccination (1 or 4 months) or the presence of maternal antibodies.