Summary: Reconstruction of large full-thickness scalp defects with exposed cranial bone or dura are usually performed with free flaps. However, certain medical conditions in fragile patients may contraindicate this type of surgery. In those circumstances, Dermal Regeneration Templates (DRTs) can provide an alternative solution to flap surgery. We here report the case of a 79-year old woman presenting with a large cranial defect and exposed dura mater after developing postsurgical Pyoderma Gangrenosum and subsequent free flap failure. A one-stage salvage reconstruction was successfully performed with MATRIDERMⓇ (MedSkin Solutions Dr. Suwelack AG, Germany) and a split-thickness skin graft (STSG) with a Vacuum-Assisted Closure (VAC) dressing.
