Nature Communications (Feb 2018)
SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
- Emilia Mira,
- Lorena Carmona-Rodríguez,
- Beatriz Pérez-Villamil,
- Josefina Casas,
- María Jesús Fernández-Aceñero,
- Diego Martínez-Rey,
- Paula Martín-González,
- Ignacio Heras-Murillo,
- Mateo Paz-Cabezas,
- Manuel Tardáguila,
- Tim D. Oury,
- Silvia Martín-Puig,
- Rosa Ana Lacalle,
- Gemma Fabriás,
- Eduardo Díaz-Rubio,
- Santos Mañes
Affiliations
- Emilia Mira
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC
- Lorena Carmona-Rodríguez
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC
- Beatriz Pérez-Villamil
- Genomics and Microarray Laboratory, Medical Oncology & Surgical Pathology Departments, Instituto de Investigación Sanitaria San Carlos Hospital Clínico San Carlos, Univ. Complutense de Madrid, CIBERONC
- Josefina Casas
- Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)
- María Jesús Fernández-Aceñero
- Genomics and Microarray Laboratory, Medical Oncology & Surgical Pathology Departments, Instituto de Investigación Sanitaria San Carlos Hospital Clínico San Carlos, Univ. Complutense de Madrid, CIBERONC
- Diego Martínez-Rey
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC
- Paula Martín-González
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC
- Ignacio Heras-Murillo
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC
- Mateo Paz-Cabezas
- Genomics and Microarray Laboratory, Medical Oncology & Surgical Pathology Departments, Instituto de Investigación Sanitaria San Carlos Hospital Clínico San Carlos, Univ. Complutense de Madrid, CIBERONC
- Manuel Tardáguila
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC
- Tim D. Oury
- Department of Pathology, University of Pittsburgh
- Silvia Martín-Puig
- Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares
- Rosa Ana Lacalle
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC
- Gemma Fabriás
- Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)
- Eduardo Díaz-Rubio
- Genomics and Microarray Laboratory, Medical Oncology & Surgical Pathology Departments, Instituto de Investigación Sanitaria San Carlos Hospital Clínico San Carlos, Univ. Complutense de Madrid, CIBERONC
- Santos Mañes
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC
- DOI
- https://doi.org/10.1038/s41467-018-03079-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway.
