Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

Yong Chen; Joschka J. Buyel; Mark J. W. Hanssen; Franziska Siegel; Ruping Pan; Jennifer Naumann; Michael Schell; Anouk van der Lans; Christian Schlein; Holger Froehlich; Joerg Heeren; Kirsi A. Virtanen; Wouter van Marken Lichtenbelt; Alexander Pfeifer

doi:10.1038/ncomms11420

Nature Communications (Apr 2016)

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

Yong Chen,
Joschka J. Buyel,
Mark J. W. Hanssen,
Franziska Siegel,
Ruping Pan,
Jennifer Naumann,
Michael Schell,
Anouk van der Lans,
Christian Schlein,
Holger Froehlich,
Joerg Heeren,
Kirsi A. Virtanen,
Wouter van Marken Lichtenbelt,
Alexander Pfeifer

Affiliations

Yong Chen: Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, Germany
Joschka J. Buyel: Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, Germany
Mark J. W. Hanssen: Department of Human Biology & Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center
Franziska Siegel: Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, Germany
Ruping Pan: Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, Germany
Jennifer Naumann: Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, Germany
Michael Schell: Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, Germany
Anouk van der Lans: Department of Human Biology & Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center
Christian Schlein: Department of Biochemistry and Molecular Cell Biology, University Medical Center
Holger Froehlich: Research Training Group 1873, University of Bonn
Joerg Heeren: Department of Biochemistry and Molecular Cell Biology, University Medical Center
Kirsi A. Virtanen: Turku PET Center, Turku University Hospital
Wouter van Marken Lichtenbelt: Department of Human Biology & Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center
Alexander Pfeifer: Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, Germany

DOI: https://doi.org/10.1038/ncomms11420
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

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Exosomes are RNA-containing lipid vesicles with roles in inter-tissue crosstalk. Here the authors show that exosome release from brown adipocytes is increased upon thermogenic activation, both in vitro and in vivo, and demonstrate that serum levels of exosomal miR-92 reflect brown fat activity in humans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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