Sudan Journal of Medical Sciences (Dec 2022)

Association Between Hemoglobin A1C and the Severity of Acute Ischemic Stroke in Sudanese Patients in Omdurman Military Hospital

  • Omer Abdalla Elamin Abdelgadir*,
  • Amal Mahmoud Saeed,
  • Abubaker Shadoul Mohamed Farah,
  • Mohanad Elsebty Mohammed Alhassan Ahmed,
  • Mogahid Ahmed Osman Farah,
  • Abdelhadi Ahmed Abdelhadi Elsayed,
  • Awab Abdalhafiz Altahir Ahmedelbasheir,
  • Mahmoud Saeed Saad Mahgoub,
  • Ahmed Khalafalla Mohamed Ahmed

DOI
https://doi.org/10.18502/sjms.v17i4.1254
Journal volume & issue
Vol. 17, no. 4
pp. 485 – 497

Abstract

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Abstract Background: Hemoglobin A1C (HbA1c) levels are known to be linked to a higher risk of stroke. However, no research data is available on the impact of HbA1C on the severity of acute ischemic stroke in Sudan. Methods: This study is a descriptive, cross-sectional hospital-based study of 40 cases of acute ischemic stroke. Ischemic stroke was confirmed using computed tomography (CT) scan at admission; all subjects' blood HbA1C levels were also measured. Participants were divided into two subgroups based on HbA1C at admission, good glycemic control (GGC) ( 7 HbA1C), and neurological impairment was assessed using the National Institutes of Health Stroke Scale (NIHSS). Results: The age distribution of the participants was 45-85 years, with an average age of 63.5 ± 9.2 years with the highest frequency (67.5%) in the age group of 55-75 years. PGC had a statistically significant high HbA1C value of 8.9 ± 1.3 (P=0.000), when compared to GGC subgroups 5.1 ± 0. The association between stroke severity and HbA1C levels on admission in this study was statistically significant (P value=0.005), on admission (78.6%) PGC had moderate to severe stroke ( > 18.8 NIHSS) versus (33.3%) that of the GGC ( > 10.4NIHSS).The frequency of elevated HbA1C levels in patients with acute ischemic stroke was 70% in this study. Conclusion: PGC was shown to be linked to the occurrence of stroke and to its severity.

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