The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

Philippe Coulombe; Joelle Nassar; Isabelle Peiffer; Slavica Stanojcic; Yvon Sterkers; Axel Delamarre; Stéphane Bocquet; Marcel Méchali

doi:10.1038/s41467-019-10321-x

Nature Communications (Jun 2019)

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

Philippe Coulombe,
Joelle Nassar,
Isabelle Peiffer,
Slavica Stanojcic,
Yvon Sterkers,
Axel Delamarre,
Stéphane Bocquet,
Marcel Méchali

Affiliations

Philippe Coulombe: Institute of Human Genetics, UMR 9002, CNRS-Université de Montpellier
Joelle Nassar: Institute of Human Genetics, UMR 9002, CNRS-Université de Montpellier
Isabelle Peiffer: Institute of Human Genetics, UMR 9002, CNRS-Université de Montpellier
Slavica Stanojcic: CNRS 5290 - IRD 224 - University of Montpellier (UMR “MiVEGEC”)
Yvon Sterkers: CNRS 5290 - IRD 224 - University of Montpellier (UMR “MiVEGEC”)
Axel Delamarre: Institute of Human Genetics, UMR 9002, CNRS-Université de Montpellier
Stéphane Bocquet: Institute of Human Genetics, UMR 9002, CNRS-Université de Montpellier
Marcel Méchali: Institute of Human Genetics, UMR 9002, CNRS-Université de Montpellier

DOI: https://doi.org/10.1038/s41467-019-10321-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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DNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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