Efficacy of Tamponade of Vitreal Cavity by Perfluororganic Compound Emulsion with Antibiotics Solutions in Treatment of Gram Negative Endopthalmitis (Experimental Study)

Abstract

The purpose of investigation was assessment of efficacy of the method suggested for treatment of postoperative endophthalmitis on the experimental model of gram negative endophthalmitis. Materials and methods. In order to create experimental model of endophthalmitis phacoemulsification of lens was rendered on 30 rabbits (30 eyes). At the end of surgery 0.1 ml of Escherichia coli microbial suspension containing 100 cells of pathogen was injected intravitreally to all. In 12 hours after the contamination signs of heavy postoperative endophthalmitis appeared in all rabbits. All the rabbits were divided into two groups in dependence of the method of further surgical treatment. 15 rabbits (15 eyes) were in the first group, vitrectomy with intravitreal injection of 1 mg vancomicin + 2.25 mg ceftazidim antibiotics combination was rendered. For 15 rabbits (15 eyes) of the second group vitrectomy with tamponade of vitreal cavity by PFOC and 1 mg vancomicin + 2.25 mg ceftazidim antibiotics combination intravitreal injection was rendered. Results. Treatment of the second group rabbits was more effective in comparison with the first group (p = 0.0018). According to ERG data visual functions were saved in 6 rabbits of the first group (40 %) and in 10 rabbits of the second group (66.67 %). Besides functional loss anatomic loss of eye was observed in 33.33 % cases in the first group. While eyeball was saved in all 100 % cases of the second group with use of the suggested method. Conclusion. Experimental investigation proved efficacy of the suggested method of endophthalmitis treatment. This method of treatment is universal regardless of disease etiological cause.

Keywords

• endophthalmitis
• vitrectomy
• perfluorodecalin
• vancomicin and ceftazidim intravitreal injection