Histological and morphometric characteristics of supratentorial meningiomas of the brain

Abstract

Aims. Histological and morphometric investigation was performed in this work, using meningioma samples, obtained during neurosurgical treatment. Methods and results. It is shown that the cross sectional area of the nuclei of tumor cells in benign meningiomas in different subtypes is characterized by similar dimensions. The density of the cells depends on the extent of fi brosis and calcifi cation in various subtypes of benign meningiomas. Conclusion. Cross-sectional area of the nuclei of tumor cells and density of their location is increased in atypical and anaplastic meningiomas, which refl ects the increasing degree of atypia. This indicates the expediency of using a morphometric method for improving the diagnosis and grading of these tumors.

Keywords

• meningioma
• nuclear morphometry
• cell density