Association of <i>Fatty Acid Desaturase 1</i> rs174547 Polymorphism with the Composition of Long-Chain Polyunsaturated Fatty Acids in Serum Glycerophospholipids during Pregnancy

Terue Kawabata; Hideoki Fukuoka; Michiru Harada; Kumiko Shoji; Yoshinori Kubo; Chisato Mori; Kenichi Sakurai; Takeshi Ohkubo; Kyoichi Oshida; Yuichiro Yamashiro

doi:10.3390/nu15030722

Nutrients (Jan 2023)

Association of <i>Fatty Acid Desaturase 1</i> rs174547 Polymorphism with the Composition of Long-Chain Polyunsaturated Fatty Acids in Serum Glycerophospholipids during Pregnancy

Terue Kawabata,
Hideoki Fukuoka,
Michiru Harada,
Kumiko Shoji,
Yoshinori Kubo,
Chisato Mori,
Kenichi Sakurai,
Takeshi Ohkubo,
Kyoichi Oshida,
Yuichiro Yamashiro

Affiliations

Terue Kawabata: Faculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Japan
Hideoki Fukuoka: Department of Perinatal Mesenchymal Stem Cell Research, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan
Michiru Harada: Faculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Japan
Kumiko Shoji: Faculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Japan
Yoshinori Kubo: Faculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Japan
Chisato Mori: Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Kenichi Sakurai: Department of Nutrition and Metabolic Medicine, Center for Preventive Medical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
Takeshi Ohkubo: Department of Health Nutrition, Faculty of Human Sciences, Sendai Shirayuri Women’s College, 6-1 Honda-Cho, Izumi-ku, Sendai 981-3107, Japan
Kyoichi Oshida: Department of Pediatrics, Juntendo University, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan
Yuichiro Yamashiro: Probiotics Research Laboratory, Graduate School of Medicine, Juntendo University, 2-9-8-3F, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

DOI: https://doi.org/10.3390/nu15030722
Journal volume & issue: Vol. 15, no. 3
p. 722

Abstract

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The increase in fetal requirements of long-chain polyunsaturated fatty acids (LCPUFAs) during pregnancy alters maternal fatty acid metabolism, and therefore, fatty acid desaturase (FADS) gene polymorphisms may change blood fatty acid composition or concentration differently during pregnancy. We investigated the relationship between a FADS1 single-nucleotide polymorphism (SNP) and maternal serum LCPUFA levels in Japanese pregnant women during the first and third trimesters and at delivery. Two hundred and fifty-three pregnant women were included, and fatty acid compositions of glycerophospholipids in serum (weight %) and the FADS1 SNP rs174547 (T/C) were analyzed. LCPUFAs, including arachidonic acid (ARA) and docosahexaenoic acid (DHA), significantly decreased from the first to the third trimester of pregnancy. Furthermore, DHA significantly decreased from the third trimester of pregnancy to delivery. At all gestational stages, linoleic acid (LA) and α-linolenic acid were significantly higher with the number of minor FADS1 SNP alleles, whereas γ-linolenic acid and ARA and the ARA/LA ratio were significantly lower. DHA was significantly lower with the number of minor FADS1 SNP alleles only in the third trimester and at delivery, suggesting that genotype effects become more obvious as pregnancy progresses.

Published in Nutrients

ISSN: 2072-6643 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.mdpi.com/journal/nutrients

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