Case Reports in Oncology (Jan 2019)

Successful Treatment with Taxane-Based Chemotherapy in Advanced Sebaceous Carcinoma: A Case Report and Literature Review

  • Shuji Ota,
  • Takahiko Sakamoto,
  • Ryosuke Ochiai,
  • Terunobu Haruyama,
  • Masashi Ishihara,
  • Maika Natsume,
  • Yoko Fukasawa,
  • Shigeru Tanzawa,
  • Ryo Usui,
  • Takeshi Honda,
  • Yasuko Ichikawa,
  • Kiyotaka Watanabe,
  • Yuko Sasajima,
  • Atsushi Mizota,
  • Nobuhiko Seki

DOI
https://doi.org/10.1159/000493850
Journal volume & issue
Vol. 12, no. 1
pp. 47 – 52

Abstract

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For sebaceous carcinoma (SC), a rare malignant tumor, no standard chemotherapy regimen for patients with distant metastasis has been studied. We experienced a case of eyelid SC with multiple lung metastases that responded to combination chemotherapy with carboplatin and paclitaxel with 11-month progression-free survival (PFS). This patient also responded to second-line treatment with docetaxel, another taxane, with 7-month PFS, resulting in at least 18 months of survival at the time of reporting. This report shows that taxane-based chemotherapy may be effective for advanced SC, for which no standard therapy has been established.

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