MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis

Marco Bocchetti; Piera Grisolia; Federica Melisi; Maria Grazia Ferraro; Pietro De Luca; Angelo Camaioni; Michela Falco; Marianna Abate; Gabriella Misso; Roberto Alfano; Nunzio Accardo; Flavia Oliva; Alessia Maria Cossu; Michele Caraglia; Marianna Scrima; Filippo Ricciardiello

doi:10.3390/cancers14215304

Cancers (Oct 2022)

MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis

Marco Bocchetti,
Piera Grisolia,
Federica Melisi,
Maria Grazia Ferraro,
Pietro De Luca,
Angelo Camaioni,
Michela Falco,
Marianna Abate,
Gabriella Misso,
Roberto Alfano,
Nunzio Accardo,
Flavia Oliva,
Alessia Maria Cossu,
Michele Caraglia,
Marianna Scrima,
Filippo Ricciardiello

Affiliations

Marco Bocchetti: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, Italy
Piera Grisolia: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, Italy
Federica Melisi: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, Italy
Maria Grazia Ferraro: Department of Pharmacy, School of Medicine and Surgery, University of Naples “Federico II”, Via D. Montesano 49, 80131 Naples, Italy
Pietro De Luca: Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy
Angelo Camaioni: Otolaryngology Department, San Giovanni-Addolorata Hospital, Via dell’Amba Aradam, 8, 00184 Rome, Italy
Michela Falco: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, Italy
Marianna Abate: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, Italy
Gabriella Misso: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, Italy
Roberto Alfano: Department of Advanced Medical and Surgical Sciences “DAMSS”, University of Campania “Luigi Vanvitelli”, Via S.M. di Costantinopoli 104, 80138 Naples, Italy
Nunzio Accardo: Ear Nose Throt Departement AORN Cardarelli, 80100 Napoli, Italy
Flavia Oliva: Ear Nose Throt Departement AORN Cardarelli, 80100 Napoli, Italy
Alessia Maria Cossu: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, Italy
Michele Caraglia: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 7, 80138 Naples, Italy
Marianna Scrima: Laboratory of Precision and Molecular Oncology, Biogem Scarl, Institute of Genetic Research, Contrada Camporeale, 83031 Ariano Irpino, Italy
Filippo Ricciardiello: Ear Nose Throt Departement AORN Cardarelli, 80100 Napoli, Italy

DOI: https://doi.org/10.3390/cancers14215304
Journal volume & issue: Vol. 14, no. 21
p. 5304

Abstract

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Salivary gland cancer (SGC) is an uncommon and heterogeneous disease that accounts for around 8.5% of all head and neck cancers. MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18–25 nucleotides) of noncoding RNA that represent key gene-transcription regulators in physiological and pathological human conditions. However, their role in SGC development and progression is not completely clear. This review aims to compile and summarize the recent findings on the topic, focusing on the prognostic and diagnostic value of the major modulated and validated microRNAs in SGC. Their differential expression could possibly aid the clinician in delivering an early diagnosis, therapeutic strategy and precision medicine.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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