Unusual Low-grade Occipito-temporal Ganglioglioma with Calcification

Abstract

Ganglioglioma (GG) is a rare benign tumour which may present as focal convulsions. Complete resection of the tumour may lead to excellent recovery. The present case report describes the features of a mixed neuronal-glial tumour in a young female patient. She complained of seizures for the last several years. Magnetic Resonance Imaging (MRI) was done. T1-weighted MRI revealed a hypointense cystic lesion in right occipitotemporal region. It measured 2.8×2.2×2.2 cm. The t2-weighted image showed a hyperintense mural nodule which measured 0.4 cm approximately. The craniotomy was done and the tumour was resected. Microscopically, the tumour showed the proliferation of astrocytes and dysplastic multinuclear neuronal cells. Dysplastic cells were large with round nuclei, abnormal clustering and irregular distribution of variably sized neurons. Few multinuclear neurons were also seen. Neoplastic neuronal cells were both synaptophysin and chromogranin A positive. Proliferated astrocytes showed pilocytic features. Eosinophilic granular bodies and perivascular inflammation were also seen. The tumour was diagnosed as a case of the World Health Organisation (WHO) Grade I ganglioglioma.

Keywords

• benign neoplasm
• dysplastic neuronal cells
• proliferated astrocytes
• seizures