Frontiers in Aging Neuroscience (Jan 2023)

Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study

  • Lisa Perus,
  • Lisa Perus,
  • Lisa Perus,
  • Lisa Perus,
  • Jean-François Mangin,
  • Jean-François Mangin,
  • Jérémy Deverdun,
  • Laure-Anne Gutierrez,
  • Emmanuelle Gourieux,
  • Clara Fischer,
  • Liesjet E. H. Van Dokkum,
  • Clara Manesco,
  • Germain Busto,
  • Germain Busto,
  • Sophie Guyonnet,
  • Sophie Guyonnet,
  • Bruno Vellas,
  • Bruno Vellas,
  • Audrey Gabelle,
  • Audrey Gabelle,
  • Emmanuelle Le Bars,
  • The MAPT/DSA group,
  • Bruno Vellas,
  • Sophie Guyonnet,
  • Isabelle Carrié,
  • Lauréne Brigitte,
  • Catherine Faisant,
  • Françoise Lala,
  • Julien Delrieu,
  • Hélène Villars,
  • Emeline Combrouze,
  • Carole Badufle,
  • Audrey Zueras,
  • Sandrine Andrieu,
  • Christelle Cantet,
  • Christophe Morin,
  • Gabor Abellan Van Kan,
  • Charlotte Dupuy,
  • Yves Rolland,
  • Céline Caillaud,
  • Pierre-Jean Ousset,
  • Françoise Lala,
  • Sherry Willis,
  • Sylvie Belleville,
  • Brigitte Gilbert,
  • Francine Fontaine,
  • Jean-François Dartigues,
  • Isabelle Marcet,
  • Fleur Delva,
  • Alexandra Foubert,
  • Sandrine Cerda,
  • Marie-Noëlle-Cuffi,
  • Corinne Costes,
  • Olivier Rouaud,
  • Patrick Manckoundia,
  • Valérie Quipourt,
  • Sophie Marilier,
  • Evelyne Franon,
  • Lawrence Bories,
  • Marie-Laure Pader,
  • Marie-France Basset,
  • Bruno Lapoujade,
  • Valérie Faure,
  • Michael Li Yung Tong,
  • Christine Malick-Loiseau,
  • Evelyne Cazaban-Campistron ,
  • Françoise Desclaux,
  • Colette Blatge,
  • Thierry Dantoine,
  • Cécile Laubarie-Mouret,
  • Isabelle Saulnier,
  • Jean-Pierre Clément,
  • Marie-Agnès Picat,
  • Laurence Bernard-Bourzeix,
  • Stéphanie Willebois,
  • Iléana Désormais,
  • Noëlle Cardinaud,
  • Marc Bonnefoy,
  • Pierre Livet,
  • Pascale Rebaudet,
  • Claire Gédéon,
  • Catherine Burdet,
  • Flavien Terracol,
  • Alain Pesce,
  • Stéphanie Roth,
  • Sylvie Chaillou,
  • Sandrine Louchart,
  • Kristel Sudres,
  • Nicolas Lebrun,
  • Nadège Barro-Belaygues,
  • Jacques Touchon,
  • Karim Bennys,
  • Audrey Gabelle,
  • Aurélia Romano,
  • Lynda Touati,
  • Cécilia Marelli,
  • Cécile Pays,
  • Philippe Robert,
  • Franck Le Duff,
  • Claire Gervais,
  • Sébastien Gonfrier,
  • Yannick Gasnier,
  • Serge Bordes,
  • Danièle Begorre,
  • Christian Carpuat,
  • Khaled Khales,
  • Jean-François Lefebvre,
  • Samira Misbah El Idrissi,
  • Pierre Skolil,
  • Jean-Pierre Salles,
  • Carole Dufouil,
  • Stéphane Lehéricy,
  • Marie Chupin,
  • Jean-François Mangin,
  • Ali Bouhayia,
  • Michèle Allard,
  • Frédéric Ricolfi,
  • Dominique Dubois,
  • Marie Paule Bonceour Martel,
  • François Cotton,
  • Alain Bonafé,
  • Stéphane Chanalet,
  • Françoise Hugon,
  • Fabrice Bonneville,
  • Christophe Cognard,
  • François Chollet,
  • Pierre Payoux,
  • Thierry Voisin,
  • Julien Delrieu,
  • Sophie Peiffer,
  • Anne Hitzel,
  • Michèle Allard,
  • Michel Zanca,
  • Jacques Monteil,
  • Jacques Darcourt,
  • Laurent Molinier,
  • Hélène Derumeaux,
  • Nadège Costa,
  • Bertrand Perret,
  • Claire Vinel,
  • Sylvie Caspar-Bauguil,
  • Pascale Olivier-Abbal,
  • Sandrine Andrieu,
  • Christelle Cantet,
  • Nicola Coley

DOI
https://doi.org/10.3389/fnagi.2022.971220
Journal volume & issue
Vol. 14

Abstract

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IntroductionThe impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC).MethodsTo determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints.ResultsNo global change in FC was detected after uni or multidomain preventive interventions. However, an effect of omega-3 fatty acid supplementation dependent on cognitive decline status was underlined for frontoparietal, salience, visual and sensorimotor networks FC. These findings were independent of the cortical thickness and vascular burden.DiscussionThese results emphasize the importance of patient stratification, based on risk factors, for preventive interventions.

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