Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology

Sara Makhdoum, MD; M. Ruhul Quddus, MD, M. Phil (Path); Michele M. Lomme, MD; Katrine Hansen, MD; W. Dwayne Lawrence, MD, MSc (Path)

Human Pathology: Case Reports (Mar 2019)

Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology

Sara Makhdoum, MD,
M. Ruhul Quddus, MD, M. Phil (Path),
Michele M. Lomme, MD,
Katrine Hansen, MD,
W. Dwayne Lawrence, MD, MSc (Path)

Affiliations

Sara Makhdoum, MD: Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USA; King Faisal Specialist Hospital and Research Center, Department of Pathology and Laboratory Medicine, Riyadh, Saudi Arabia
M. Ruhul Quddus, MD, M. Phil (Path): Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USA; Corresponding author at: Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USA.
Michele M. Lomme, MD: Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USA
Katrine Hansen, MD: Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USA
W. Dwayne Lawrence, MD, MSc (Path): Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USA

Journal volume & issue: Vol. 15
pp. 92 – 94

Abstract

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A 63-year-old Caucasian woman underwent total hysterectomy with bilateral salpingo-oophorectomy due to abnormal uterine bleeding. Gross examination of the hysterectomy specimen revealed a large polypoid mass filling the endometrial cavity. Histological examination revealed a tumor with two unique morphologic patterns with no overlap or transition from one pattern to the other. The low-grade component consisted of FIGO grade 1 endometrioid adenocarcinoma with unusual “balloon-cell” change, while the high grade component was an undifferentiated carcinoma with neuroendocrine features. Both components exhibited MLH1 and MSH6 loss by immunohistochemistry. To our knowledge, the current case is only the 5th documented case of dedifferentiated endometrioid carcinoma with neuroendocrine features. Keywords: Endometrium, Dedifferentiated carcinoma, Neuroendocrine features, Balloon-cell change, Microsatellite instability

Published in Human Pathology: Case Reports

ISSN: 2214-3300 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Pathology
Website: http://www.journals.elsevier.com/human-pathology-case-reports/

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