Successful pregnancy with donor eggs in-vitro fertilization after premature ovarian insufficiency in a tertiary hospital in a low-income setting: a case report

Fertility Research and Practice. 2016;2(1):1-6 DOI 10.1186/s40738-016-0028-3


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Journal Title: Fertility Research and Practice

ISSN: 2054-7099 (Online)

Publisher: BMC

LCC Subject Category: Medicine: Nursing | Medicine: Pediatrics

Country of publisher: United Kingdom

Language of fulltext: English

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Thomas Obinchemti Egbe (Faculty of Health Sciences, University of Buea)
Carine Youta Wafo (Clinique de l’Aeroport)
Berthe Bebey Bollo (CMA Congo)
Christian Pany (Biomedicam Laboratory)
Monique Jong Onomo (Clinique de l’Aeroport)
Guy Sandjon (Clinique de l’Aeroport)


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Time From Submission to Publication: 8 weeks


Abstract | Full Text

Abstract Background Premature Ovarian Insufficiency (POI) is classically defined as 4–6 months of cessation of menses (amenorrhea) in women under 40, associated with menopausal level of serum gonadotropins FSH > 40 IU/L and hypo-estrogenism and is also referred to as hypergonadotropic hypogonadism. This disorder can manifest as primary amenorrhea without the onset of menses (menarche), or as secondary amenorrhea after menarche and pubertal development. The diagnosis of this condition in Cameroon is sometimes difficult because of the high cost of hormonal assays and the few laboratories offering these services. Case presentation The patient was a 38-year-old G2P0020, blood group O Rh positive, genotype AA and BMI 19 kg/m2 who came to our service because of secondary amenorrhea and infertility of 2 years’ duration. She has a history of pulmonary tuberculosis that was treated in Cameroon. After laparoscopy and hormonal profile, the diagnosis of premature ovarian insufficiency was reached. The woman underwent a successful donor egg in-vitro fertilization cycle and delivered a female fetus. Two years later YE requested IVF with autologous eggs, which was not possible, and since then she has remained with one child. Conclusion The diagnosis of premature ovarian insufficiency is difficult in Cameroon because of the high cost of laboratory investigations and difficult access to the tests. In-vitro fertilization with donor egg is a better treatment option. Unfortunately, it is not accessible to most Cameroonians because of lack of technical ability and the existence of cultural and financial barriers.