Full-field strain mapping for characterization of structure-related variation in corneal biomechanical properties using digital image correlation (DIC) technology

Xiaofeng Qiao; Duo Chen; Hongqiang Huo; Min Tang; Zhili Tang; Ying Dong; Xiaoyu Liu; Yubo Fan

Medicine in Novel Technology and Devices (Sep 2021)

Full-field strain mapping for characterization of structure-related variation in corneal biomechanical properties using digital image correlation (DIC) technology

Xiaofeng Qiao,
Duo Chen,
Hongqiang Huo,
Min Tang,
Zhili Tang,
Ying Dong,
Xiaoyu Liu,
Yubo Fan

Affiliations

Xiaofeng Qiao: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China
Duo Chen: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China
Hongqiang Huo: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China
Min Tang: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China
Zhili Tang: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China
Ying Dong: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China
Xiaoyu Liu: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China; Corresponding author. Office Room 404, Yifu Building in Beihang University, No.37, Xueyuan Road, Beijing, 100083, China.
Yubo Fan: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China; School of Medical Science and Engineering Medicine, Beihang University, Beijing, 100083, China; Corresponding author. Office Room 319, Yifu Building in Beihang University, No.37, Xueyuan Road, Beijing, 100083, China.

Journal volume & issue: Vol. 11
p. 100086

Abstract

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Characterization of structure-related variation in corneal biomechanical properties is important for the design of corneal implants with a controllable degradation. In the current study, we conducted an in-vitro inflation experiment on contact and structural-damaged porcine corneas and mapped the strain distribution during using digital image correlation (DIC) algorithm. The inflation experiment was performed with a pressure loading device, a steady-state pressure transducer and DIC system. Corneal samples with uniformly-distributed paint particles were fixed on the loading device, and then were subjected increasing pressure load through injection with a constant velocity (0.134 ml/min). Three-dimensional (3D) DIC algorithm was performed to present a map of the full-field strain distribution on the corneal surface. The results showed a significant difference in the strain distribution between the intact and damaged corneas. The time-strain history also exhibited differently when the two types of cornea samples were subjected to inflation. It indicated that the DIC technology is validated to characterize structure-related variation in corneal biomechanical properties.

Published in Medicine in Novel Technology and Devices

ISSN: 2590-0935 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Medical technology
Website: https://www.journals.elsevier.com/medicine-in-novel-technology-and-devices

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