Nature Communications (Aug 2022)
Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities
- Catherine M. Francis,
- Matthias E. Futschik,
- Jian Huang,
- Wenjia Bai,
- Muralidharan Sargurupremraj,
- Alexander Teumer,
- Monique M. B. Breteler,
- Enrico Petretto,
- Amanda S. R. Ho,
- Philippe Amouyel,
- Stefan T. Engelter,
- Robin Bülow,
- Uwe Völker,
- Henry Völzke,
- Marcus Dörr,
- Mohammed-Aslam Imtiaz,
- N. Ahmad Aziz,
- Valerie Lohner,
- James S. Ware,
- Stephanie Debette,
- Paul Elliott,
- Abbas Dehghan,
- Paul M. Matthews
Affiliations
- Catherine M. Francis
- National Heart and Lung Institute, Imperial College London, Programme in Cardiovascular Genetics and Genomics
- Matthias E. Futschik
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Jian Huang
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Wenjia Bai
- Department of Brain Sciences, Imperial College London
- Muralidharan Sargurupremraj
- Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Monique M. B. Breteler
- Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE)
- Enrico Petretto
- Programme in Cardiovascular & Metabolic Disorders and Centre for Computational Biology, Duke-NUS Medical School
- Amanda S. R. Ho
- Computational Biology Programme, Faculty of Science, National University of Singapore
- Philippe Amouyel
- LabEx DISTALZ-U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille
- Stefan T. Engelter
- Department of Neurology and Stroke Center, University Hospital and University of Basel
- Robin Bülow
- Department of Radiology and Neuroradiology, University Medicine Greifswald
- Uwe Völker
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- Henry Völzke
- Institute for Community Medicine, University Medicine Greifswald
- Marcus Dörr
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- Mohammed-Aslam Imtiaz
- Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE)
- N. Ahmad Aziz
- Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE)
- Valerie Lohner
- Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE)
- James S. Ware
- National Heart and Lung Institute, Imperial College London, Programme in Cardiovascular Genetics and Genomics
- Stephanie Debette
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Paul Elliott
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Abbas Dehghan
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Paul M. Matthews
- Department of Brain Sciences, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-022-32219-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Aortic distensibility is a risk factor for multiple cardiovascular events, but the genetic etiology is not well understood. Here, the authors identify genetic variants linked to aortic distensibility, highlighting mechanistic pathways and causal relationships between distensibility and both aortic aneurysms and brain small vessel disease.
