Population pharmacokinetics analysis in Lixoft Monolix softwares

Abstract

The article has discussed a step-by-step algorithm for developing population pharmacokinetics models in the Lixoft Monolix software. Features of population pharmacokinetics study’s methodology have described. Special attention is paid to the advantages of the compartmental approach and nonlinear mixed effects modeling in study of pharmacokinetics. Methods for estimating population pharmacokinetic parameters and its implementation in software are described.

Keywords

• monolix
• nlmem
• saem
• mcmc
• bayesian functional
• mle
• pk
• ppk