Nature Communications (Aug 2022)

Structure of SARS-CoV-2 membrane protein essential for virus assembly

  • Zhikuan Zhang,
  • Norimichi Nomura,
  • Yukiko Muramoto,
  • Toru Ekimoto,
  • Tomoko Uemura,
  • Kehong Liu,
  • Moeko Yui,
  • Nozomu Kono,
  • Junken Aoki,
  • Mitsunori Ikeguchi,
  • Takeshi Noda,
  • So Iwata,
  • Umeharu Ohto,
  • Toshiyuki Shimizu

DOI
https://doi.org/10.1038/s41467-022-32019-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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M protein plays essential roles in virus assembly and morphogenesis. Here, authors reveal two cryo-EM structures of M protein from SARS-CoV-2 that suggest conformational dynamics of M protein and its role in virus assembly.