Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population

Journal of Diabetes Research. 2019;2019 DOI 10.1155/2019/9302636

 

Journal Homepage

Journal Title: Journal of Diabetes Research

ISSN: 2314-6745 (Print); 2314-6753 (Online)

Publisher: Hindawi Limited

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML

 

AUTHORS


Yaroslav D. Chumachenko (Scientific Laboratory of Molecular Genetic Studies, Medical Institute of the Sumy State University, 40007, Ukraine)

Viktoriia Yu. Harbuzova (Scientific Laboratory of Molecular Genetic Studies, Medical Institute of the Sumy State University, 40007, Ukraine)

Alexander V. Ataman (Department of Physiology and Pathophysiology with Medical Biology Course, Medical Institute of the Sumy State University, 40018, Ukraine)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 14 weeks

 

Abstract | Full Text

Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both environmental and genetic factors contribute to its development. Recent studies have demonstrated that the skeleton realizes systemic regulation of energy metabolism through the secretion of osteocalcin (OCN). Thus, the association analysis between HindIII single nucleotide polymorphism of OCN gene (BGLAP) promoter region and T2DM development in Ukrainian population was carried out. 153 individuals diagnosed with T2DM and 311 control individuals were enrolled in the study. The genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The lack of association between BGLAP HindIII single nucleotide polymorphism (SNP) and T2DM development among Ukrainians was found. Further studies with extended groups of comparison are needed to confirm the obtained results.