Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications
Giovanna Romano,
Mariana Almeida,
Ana Varela Coelho,
Adele Cutignano,
Luis G Gonçalves,
Espen Hansen,
Denis Khnykin,
Tali Mass,
Andreja Ramšak,
Miguel S. Rocha,
Tiago H. Silva,
Michela Sugni,
Loriano Ballarin,
Anne-Marie Genevière
Affiliations
Giovanna Romano
Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
Mariana Almeida
3B’s Research Group, I3B’s—Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark—Parque de Ciência e Tecnologia, Barco, 4805-017 Guimarães, Portugal
Ana Varela Coelho
ITQB NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal
Adele Cutignano
Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
Luis G Gonçalves
ITQB NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal
Espen Hansen
Marbio, UiT-The Arctic University of Norway, 9037 Tromso, Norway
Denis Khnykin
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Department of Pathology, Oslo University Hospital-Rikshospitalet, 0450 Oslo, Norway
Tali Mass
Faculty of Natural Science, Department of Marine Biology, Charney School of Marine Sciences, University of Haifa, Haifa 3498838, Israel
Andreja Ramšak
National Institute of Biology, Marine Biology Station, Fornače 41, SI-6330 Piran, Slovenia
Miguel S. Rocha
3B’s Research Group, I3B’s—Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark—Parque de Ciência e Tecnologia, Barco, 4805-017 Guimarães, Portugal
Tiago H. Silva
3B’s Research Group, I3B’s—Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark—Parque de Ciência e Tecnologia, Barco, 4805-017 Guimarães, Portugal
Michela Sugni
Department of Environmental Science and Policy, University of Milan, Via Celoria, 2, 20133 Milan, Italy
Loriano Ballarin
Department of Biology, University of Padova, Via U. Bassi 58/B, 35100 Padova, Italy
Anne-Marie Genevière
Biologie Intégrative des Organismes Marins (BIOM), Observatoire Océanologique de Banyuls-sur-Mer, Sorbonne Université, CNRS, 1 Avenue Pierre Fabre, 66650 Banyuls-sur-Mer, France
Aquatic invertebrates are a major source of biomaterials and bioactive natural products that can find applications as pharmaceutics, nutraceutics, cosmetics, antibiotics, antifouling products and biomaterials. Symbiotic microorganisms are often the real producers of many secondary metabolites initially isolated from marine invertebrates; however, a certain number of them are actually synthesized by the macro-organisms. In this review, we analysed the literature of the years 2010–2019 on natural products (bioactive molecules and biomaterials) from the main phyla of marine invertebrates explored so far, including sponges, cnidarians, molluscs, echinoderms and ascidians, and present relevant examples of natural products of interest to public and private stakeholders. We also describe omics tools that have been more relevant in identifying and understanding mechanisms and processes underlying the biosynthesis of secondary metabolites in marine invertebrates. Since there is increasing attention on finding new solutions for a sustainable large-scale supply of bioactive compounds, we propose that a possible improvement in the biodiscovery pipeline might also come from the study and utilization of aquatic invertebrate stem cells.
