Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors

Marcin Wegrecki; Tonatiuh A. Ocampo; Sachith D. Gunasinghe; Anouk von Borstel; Shin Yi Tin; Josephine F. Reijneveld; Thinh-Phat Cao; Benjamin S. Gully; Jérôme Le Nours; D. Branch Moody; Ildiko Van Rhijn; Jamie Rossjohn

doi:10.1038/s41467-022-31443-9

Nature Communications (Jul 2022)

Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors

Marcin Wegrecki,
Tonatiuh A. Ocampo,
Sachith D. Gunasinghe,
Anouk von Borstel,
Shin Yi Tin,
Josephine F. Reijneveld,
Thinh-Phat Cao,
Benjamin S. Gully,
Jérôme Le Nours,
D. Branch Moody,
Ildiko Van Rhijn,
Jamie Rossjohn

Affiliations

Marcin Wegrecki: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Tonatiuh A. Ocampo: Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School
Sachith D. Gunasinghe: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Anouk von Borstel: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Shin Yi Tin: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Josephine F. Reijneveld: Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School
Thinh-Phat Cao: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Benjamin S. Gully: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Jérôme Le Nours: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
D. Branch Moody: Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School
Ildiko Van Rhijn: Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School
Jamie Rossjohn: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University

DOI: https://doi.org/10.1038/s41467-022-31443-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

T cell receptors are generally thought to contact antigens presented in an end to end configuration. Here the authors show a geometrically alternate sideways mode of recognition of the antigen-presenting molecule CD1a by a γδ T cell receptor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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