Communications Biology (Feb 2021)

Dexamethasone and lactoferrin induced PMN-MDSCs relieved inflammatory adverse events of anti-cancer therapy without tumor promotion

  • Xing Li,
  • Jie Chen,
  • Yong-Jian Chen,
  • Yi-Dan Qiao,
  • Li-Yun Zhao,
  • Nan Jiang,
  • Xiang-Yuan Wu,
  • Yan-Fang Xing

DOI
https://doi.org/10.1038/s42003-021-01769-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 12

Abstract

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Li et al. show that dexamethasone and lactoferrin induced polymorphonuclear myeloid-derived suppressor cells relieve inflammatory conditions in mouse models with minimal effect on tumour growth. This work demonstrates promise for combating inflammatory adverse events during anti-cancer treatments.