Third-Generation Sequencing in Clinical Practice: The New Era of Precision Medicine?

Abstract

In the last decades, the spreading of next-generation sequencing (NGS) in clinical practice has considerably increased the genomic knowledge of several disorders. The recent advent of third-generation sequencing is transforming the standard way of conceiving clinical genomics, overcom-ing the main limits of conventional NGS technologies and achieving challenges so far considered unreasonable. What was impracticable only a few years ago, in terms of potential and affordability, now is becoming achievable. The new sequencing era will improve diagnostic and therapeutic ap-proaches, providing clinicians with valid support in their practice.

Keywords

• third-generation sequencing
• nanopore sequencing
• clinical practice
• infectious diseases
• inherited disorders
• cancer diseases