A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma

Saiful E. Syafruddin; Paulo Rodrigues; Erika Vojtasova; Saroor A. Patel; M. Nazhif Zaini; Johanna Burge; Anne Y. Warren; Grant D. Stewart; Tim Eisen; Dóra Bihary; Shamith A. Samarajiwa; Sakari Vanharanta

doi:10.1038/s41467-019-09116-x

Nature Communications (Mar 2019)

A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma

Saiful E. Syafruddin,
Paulo Rodrigues,
Erika Vojtasova,
Saroor A. Patel,
M. Nazhif Zaini,
Johanna Burge,
Anne Y. Warren,
Grant D. Stewart,
Tim Eisen,
Dóra Bihary,
Shamith A. Samarajiwa,
Sakari Vanharanta

Affiliations

Saiful E. Syafruddin: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Paulo Rodrigues: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Erika Vojtasova: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Saroor A. Patel: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
M. Nazhif Zaini: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Johanna Burge: Academic Urology Group, Department of Surgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge Biomedical Campus
Anne Y. Warren: Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust
Grant D. Stewart: Academic Urology Group, Department of Surgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge Biomedical Campus
Tim Eisen: Department of Oncology, University of Cambridge
Dóra Bihary: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Shamith A. Samarajiwa: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
Sakari Vanharanta: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre

DOI: https://doi.org/10.1038/s41467-019-09116-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Super enhancers are frequently involved in the dysregulation of gene expression in cancer. Here, in kidney cancer, a super enhancer is shown to drive the expression of KLF6, which alters the expression of lipid metabolism genes and promotes tumorigenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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