The Association of Heart Failure and Liver T1 Mapping in Cardiac Magnetic Resonance Imaging
Adrian T. Huber,
Joanna Bartkowiak,
Robin Seitz,
Benedikt Bernhard,
Martina Boscolo Berto,
Giancarlo Spano,
Benedikt Wagner,
Verena C. Obmann,
Lukas Ebner,
Inga A. S. Todorski,
Michael P. Brönnimann,
Kady Fischer,
Dominik P. Guensch,
Andreas Christe,
Annalisa Berzigotti,
Lorenz Räber,
Tobias Reichlin,
Thomas Pilgrim,
Fabien Praz,
Christoph Gräni,
Nicholas Brugger,
Alan A. Peters
Affiliations
Adrian T. Huber
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland
Joanna Bartkowiak
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Robin Seitz
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland
Benedikt Bernhard
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Martina Boscolo Berto
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Giancarlo Spano
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Benedikt Wagner
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland
Verena C. Obmann
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland
Lukas Ebner
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland
Inga A. S. Todorski
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland
Michael P. Brönnimann
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland
Kady Fischer
Department of Anesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Dominik P. Guensch
Department of Anesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Andreas Christe
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland
Annalisa Berzigotti
Department of Hepatology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Lorenz Räber
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Tobias Reichlin
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Thomas Pilgrim
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Fabien Praz
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Christoph Gräni
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Nicholas Brugger
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Alan A. Peters
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland
Background/Objectives: The objective of this study was to investigate the association between congestive heart failure (CHF) and T1 mapping in both liver lobes using cardiac MRI. Methods: This retrospective study included patients who underwent cardiac MRI with T1 mapping sequences on a 1.5 T scanner. The liver T1 values were measured in four hepatic regions, utilizing cardiac short axis and four-chamber views. Echocardiographic and laboratory data were collected within 90 days of the cardiac MRI. Comparisons of the liver T1 values and echocardiographic parameters between patients with and without elevated NT-proBNP levels (>125 pg/mL) were conducted using the Mann–Whitney U test. Logistic regression models were employed to adjust for confounding factors. Results: A total of 397 patients were included (with a median age of 56 years; 127 females), of whom 35% (n = 138) exhibited elevated NT-proBNP levels. The patients with elevated NT-proBNP levels showed a larger end-diastolic volume (EDV: 92 vs. 81 mL/m2, p p p p p = 0.068) or the dome (590 vs. 560 ms, p = 0.1). T1 mapping in the caudate (OR 1.013, 95% CI 1.004–1.023, p = 0.005) and right liver lobes (OR 1.012, 95% CI 1.003–1.021, p = 0.009) remained independently predictive in the logistic regression analysis. Conclusions: Elevated T1 values in the caudate and right liver lobes assessed by cardiac MRI were independently associated with CHF and outperformed T1 measurements in the left liver lobe in predicting disease.
