Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC)

• Jiaxin Hong,
• Yao-An Shen,
• Chih-Yi Hsu,
• Peng Huang,
• Alicja Tomaszewski,
• Edward Gabrielson,
• Ie-Ming Shih,
• Stephanie Gaillard,
• Tian-Li Wang

Affiliations

Jiaxin Hong

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Baltimore, MD 21231, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China

Yao-An Shen

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Baltimore, MD 21231, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Corresponding author. Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Room 376, CRB2, 1550 Orleans Street, Baltimore, MD 21231, USA.

Chih-Yi Hsu

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

Peng Huang

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Baltimore, MD 21231, USA

Alicja Tomaszewski

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Baltimore, MD 21231, USA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

Edward Gabrielson

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Baltimore, MD 21231, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

Ie-Ming Shih

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Baltimore, MD 21231, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

Stephanie Gaillard

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Baltimore, MD 21231, USA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

Tian-Li Wang

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Baltimore, MD 21231, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Corresponding author. Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Room 306, CRB2, 1550 Orleans Street, Baltimore, MD 21231, USA.