Encephalitis with Antibodies Against Glial Fibrillary Acidic Protein (GFAP) After Allogeneic Hematopoietic Stem Cell Transplantation: A Rare Case Report and Literature Review

Abstract

Jing Liu, Ping Yang, Meng Hu Department of Hematology, First Affiliated Hospital of Henan University of Science and Technology, Henan, 471000, People’s Republic of ChinaCorrespondence: Meng Hu, Department of Hematology, First Affiliated Hospital of Henan University of Science and Technology, Henan, 471000, People’s Republic of China, Email [email protected]: In this report, the patient was a 57-year-old woman who had been diagnosed with aplastic anemia for 3 years. This patient underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). Twenty-four months after allo-HSCT, the patient experienced cognitive dysfunction, memory loss, and involuntary movements. Various central nervous system (CNS) complications may occur after allo-HSCT, which can lead to severe clinical problems. Diagnosis is often difficult because of the absence of distinctive clinical symptoms. In addition, different neurological disorders may show similar symptoms. Although antibodies in the CSF or serum have become well recognized in several CNS disorders, cases of autoimmune CNS disorders after allo-HSCT have rarely been reported. Here, we report the case of a patient who developed encephalitis associated with antibodies against glial fibrillary acidic protein (GFAP) after allo-HSCT. To the best of our knowledge, this is the first report of the involvement of antibodies against GFAP in post-transplantation encephalitis. Of course, all processes met the ethical and patient consents were obtained.Keywords: glial fibrillary acidic protein, autoimmune encephalitis, allo-HSCT

Keywords

• glial fibrillary acidic protein
• autoimmune encephalitis
• allo-hsct