IMPROVING ANTIRETROVIRAL THERAPY IN CHILDREN WITH HIV INFECTION

Abstract

The objective — to characterize the effectiveness of different schemes of antiretroviral therapy in children with HIV infection and on the basis of the obtained data to improve of the disease treatment.Patients and Methods: A clinical, immunological and virological examination of 45 children with HIV infection were carried. Patients received antiretroviral therapy — abacavire and lamivudine in combination with lopinavir/ritonavir (24 patients) or nevirapine (21 children).Results: Using both antiretroviral therapy schemes leads to suppression of HIV replication, improvement of clinical and immunological parameters. However, the treatment with lopinavir/ritonavir revealed a significant positive changes of HIV blood viral load, immune status and clinical picture. Testing of clinical and laboratory parameters prior to treatment in the Cox hazard model showed that the independent predictor of prolonging the effectiveness of therapy is the lopinavir/ritonavir use. As a side effect of lopinavir/ritonavir developed dyspeptic symptoms.Conclusion: High efficiency and safety of lopinavir/ritonavir allow us to recommend the inclusion of this drug in the selection schemes of antiretroviral therapy in HIV infected children.

Keywords

• hiv infection
• children
• antiretroviral therapy
• lopinavir/ritonavir
• nevirapine