Preventive effects of betamethasone valerate ointment for radiation-induced severe oral mucositis in patients with oral or oropharyngeal cancer: protocol for a multicentre, phase II, randomised controlled trial (Bet-ROM study)

• Yumiko Kawashita,
• Masahiro Umeda,
• Toshiyuki Saito,
• Sakiko Soutome,
• Maho Murata,
• Masako Yoshimatsu,
• Madoka Funahara,
• Mitsunobu Otsuru,
• Yoshiko Yamamura,
• Takumi Hasegawa,
• Shin-ichi Yamada,
• Yuka Kojima,
• Hirokazu Nakahara,
• Yasuyuki Shibuya

Affiliations

Yumiko Kawashita

Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Masahiro Umeda

Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Toshiyuki Saito

Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Sakiko Soutome

Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Maho Murata

Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Masako Yoshimatsu

Oral Management Center, Nagasaki University Hospital, Nagasaki, Japan

Madoka Funahara

Kyushu Dental University, School of Oral Health, Fukuoka, Japan

Mitsunobu Otsuru

Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Yoshiko Yamamura

Department of Oral Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, UK

Takumi Hasegawa

Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

Shin-ichi Yamada

Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Japan

Yuka Kojima

Department of Dentistry and Oral Surgery, Kansai Medical University, Osaka, Japan

Hirokazu Nakahara

Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan

Yasuyuki Shibuya

Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan