An Investigation of the Protective Effects of the Hydroalcoholic Extract of Persian Yellow Rose (Rosa foetida Herrm.) on Rats with Parkinson's Disease Induced by 6-Hydroxydopamine

Abstract

Background and Aim: This study was carried out to investigate the protective impacts of Rosa foetida extract on Parkinson's disease. Materials and Methods: Seventy rats were divided into 7 groups of 10, including a sham group, the Parkinsonian group (received 6OHDA), pretreatment and post-treatment groups with Persian yellow rose extract (150 mg/kg and 300 mg/kg), and the positive control (L-DOPA). Animal behavior was evaluated using behavioral tests, including muscle stiffness test, rotarod, and elevated body swing test (EBST). The data were analyzed using SPSS statistical software. Results: The frequency of turning to the right in the EBST test, the muscle stiffness score, and the right as well as left-hand scores in the muscle stiffness test were significantly higher in the Parkinsonian group than in the sham group (P<0.05). The frequency of turning to the right in the post-treatment group with Persian yellow rose extract in doses 150 and 300 mg/kg and in pre-treatment with Persian yellow rose extract in dose 300 was significantly lower than that of the Parkinsonian group (P<0.05). The score of the left and right hand in the pre-treatment group of Persian yellow rose extract at a dose of 300 significantly decreased compared with the Parkinsonian group (P<0.05). The time to maintain balance in the rotarod test was significantly reduced in the Parkinsonian group compared with the sham, and post-treatment as well as pre-treatment groups with different doses of Persian yellow rose extract (P<0.05). Conclusion: According to the results of this study, it can be said that the Persian yellow rose extract protects nerve cells against oxidative damage caused by 6-hydroxydopamine and improves motor symptoms and balance disorders caused by Parkinson's disease.

Keywords

• Persian yellow rose, Parkinson, Dopamine, L-DOPA, Rat