Drug Design, Development and Therapy (Jan 2019)
Letter regarding the article, “A randomized, double-blind clinical trial of canrenone vs hydrochlorothiazide in addition to angiotensin II receptor blockers in hypertensive type 2 diabetic patients”
Abstract
Ling-Yue Zhao, Yi-Jun Luo, Jing Zhu Department of Ambulatory Surgery, Shenzhen Nanshan District People’s Hospital, Shenzhen, Guangdong 518052, People’s Republic of China Previous studies have confirmed the utility of canrenone to control inflammation, microalbuminuria, and cardiovascular risk.1,2 Recently, we read with great interest the study by Derosa et al.3 The authors performed a randomized, double-blind clinical trial to compare the effectiveness of canrenone vs hydrochlorothiazide (HCTZ) in addition to angiotensin II receptor blockers (ARBs) in patients with hypertension and type 2 diabetes mellitus. The primary endpoints were blood pressure, glycemia, lipid profile, potassium, aldosterone, and renal function. They concluded that the effect on blood pressure was similar between canrenone and HCTZ. Nevertheless, the metabolic parameters were improved in patients taking canrenone; thus, it was worsened in those receiving HCTZ. The research appears informative clinically. Thus, some issues should be addressed in interpreting the results. View the original paper by Derosa and colleagues.
