Assessing the frequency of bacterial agents of newborn septicemia and detection of their resistance to antibiotics in Hamadan during 1998-99

Abstract

Objective: Bacterial septicemia is one of the most common causes of neonatal mortality and morbidity especially in developing countries. The objective of the present study was to identify the bacterial agents of septicemia, detection of their resistance and consideration of other septicemia factors. Methods: In order to find out the causative agents in Hamadan, a cross-sectional study was carried out on 620 neonates suspected of contracting bacterial septicemia. Antibiotic resistance tests were done by gel-diffusion method of Kirby-Bauer. Findings: The results indicated that 104 cases of 620 blood cultures (16.8%) were positive, the most common isolated bacteria included pseudomonas 26.9%, Klebsiella 25%, Staph aureus 14.4%, E.coli 13.5% and Staph epidermitis 7.7%. There was a high risk of infection among neonates weighing 1000-1500 gr. The results of antibiotic resistance showed that gram-positive and gram-negative bacteria were sensitive to Ciprofloxacine and Ceftizoxime. Conclusion: This study showed that septicemia is one of the major problems in neonatal in our country, thus more professional vigilance is required.

Keywords

• neonates
• septicemia
• bacterial agents
• drug resistance