Trained Innate Immunity Induced by Vaccination with Low-Virulence
<i>Candida</i>
Species Mediates Protection against Several Forms of Fungal Sepsis via Ly6G
<sup>+</sup>
Gr-1
<sup>+</sup>
Leukocytes
Elizabeth A. Lilly,
Breah E. Bender,
Shannon Esher Righi,
Paul L. Fidel,
Mairi C. Noverr
Affiliations
Elizabeth A. Lilly
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA
Breah E. Bender
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA
Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA
Trained innate immunity (TII) is induced following immunization with live attenuated microbes and represents a clinically important strategy to enhance innate defenses. TII was initially demonstrated following intravenous inoculation with low-virulence Candida albicansC. albicans
