Preserved functional organization of auditory cortex in two individuals missing one temporal lobe from infancy
Tamar I. Regev,
Benjamin Lipkin,
Dana Boebinger,
Alexander Paunov,
Hope Kean,
Sam V. Norman-Haignere,
Evelina Fedorenko
Affiliations
Tamar I. Regev
Brain and Cognitive Sciences Department, Massachusetts Institute of Technology, Cambridge, MA, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Corresponding author
Benjamin Lipkin
Brain and Cognitive Sciences Department, Massachusetts Institute of Technology, Cambridge, MA, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Corresponding author
Dana Boebinger
Department of Biostatistics & Computational Biology, University of Rochester Medical Center, Rochester, NY, USA; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA
Alexander Paunov
INSERM-CEA Cognitive Neuroimaging Unit (UNICOG), NeuroSpin Center, Gif sur Yvette, France
Hope Kean
Brain and Cognitive Sciences Department, Massachusetts Institute of Technology, Cambridge, MA, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA
Sam V. Norman-Haignere
Department of Biostatistics & Computational Biology, University of Rochester Medical Center, Rochester, NY, USA; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA; Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY, USA
Evelina Fedorenko
Brain and Cognitive Sciences Department, Massachusetts Institute of Technology, Cambridge, MA, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Speech and Hearing Bioscience and Technology (SHBT) Program, Harvard University, Boston, MA, USA; Corresponding author
Summary: Human cortical responses to natural sounds, measured with fMRI, can be approximated as the weighted sum of a small number of canonical response patterns (components), each having interpretable functional and anatomical properties. Here, we asked whether this organization is preserved in cases where only one temporal lobe is available due to early brain damage by investigating a unique family: one sibling missing their left temporal lobe from infancy, another missing the right temporal lobe from infancy, and a third anatomically neurotypical. None of the siblings manifested behavioral deficits. We analyzed fMRI responses to diverse natural sounds within the intact hemispheres of these individuals and compared them to 12 neurotypical participants. All siblings manifested typical-like auditory responses in their intact hemispheres. These results suggest that the development of the auditory cortex in each hemisphere does not depend on the existence of the other hemisphere, highlighting the redundancy and equipotentiality of the bilateral auditory system.
