Nature Communications (May 2021)

Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease

  • Hideaki Matsui,
  • Junko Ito,
  • Noriko Matsui,
  • Tamayo Uechi,
  • Osamu Onodera,
  • Akiyoshi Kakita

DOI
https://doi.org/10.1038/s41467-021-23452-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Mitochondrial and lysosomal dysfunction are central to Parkinson’s disease (PD) pathogenesis. Here, the authors show mitochondrial dsDNA in the cytosol in cellular and Zebrafish models of PD induces cytotoxicity and neurodegeneration; knock-down of IFI16, a cytosolic dsDNA sensor, rescues cytotoxicity, as does overexpression of lysosomal DNAse II.