Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report
Kiyofumi Takabatake,
Keisuke Nakano,
Hotaka Kawai,
Saori Yoshida,
Haruka Omori,
May Wathone Oo,
Shan Qiusheng,
Kenichiro Uchida,
Katsuaki Mishima,
Hitoshi Nagatsuka
Affiliations
Kiyofumi Takabatake
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008525, Japan
Keisuke Nakano
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008525, Japan
Hotaka Kawai
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008525, Japan
Saori Yoshida
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008525, Japan
Haruka Omori
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008525, Japan
May Wathone Oo
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008525, Japan
Shan Qiusheng
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008525, Japan
Kenichiro Uchida
Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi 7558505, Japan
Katsuaki Mishima
Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi 7558505, Japan
Hitoshi Nagatsuka
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008525, Japan
Secretory carcinoma (SC) is a recently described salivary gland tumor reported in the fourth edition of World Health Organization classification of head and neck tumors. SC is characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression, and harbors a t(12;15)(p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, SC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretion. SC is generally recognized as low-grade malignancy with low-grade histopathologic features, and metastasis is relatively uncommon. In this case, we described a SC of hard palate that underwent high grade transformation and metastasis to the cervical lymph node in a 54-year-old patient. In addition, this case showed different histological findings between primary lesion and metastasis lesion. Therefore, the diagnosis was confirmed by the presence of ETV6 translocation. Here, we report a case that occurred SC with high-grade transformation in the palate, and a review of the relevant literature is also presented.
