Nature Communications (Oct 2018)
Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation
- Erik L. Johnson,
- Nicole A. Doria-Rose,
- Jason Gorman,
- Jinal N. Bhiman,
- Chaim A. Schramm,
- Ashley Q. Vu,
- William H. Law,
- Baoshan Zhang,
- Valerie Bekker,
- Salim S. Abdool Karim,
- Gregory C. Ippolito,
- Lynn Morris,
- Penny L. Moore,
- Peter D. Kwong,
- John R. Mascola,
- George Georgiou
Affiliations
- Erik L. Johnson
- Department of Chemical Engineering, The University of Texas at Austin
- Nicole A. Doria-Rose
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jason Gorman
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jinal N. Bhiman
- Center for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS)
- Chaim A. Schramm
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Ashley Q. Vu
- Department of Molecular Biosciences, The University of Texas at Austin
- William H. Law
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Baoshan Zhang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Valerie Bekker
- Center for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS)
- Salim S. Abdool Karim
- Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal
- Gregory C. Ippolito
- Department of Molecular Biosciences, The University of Texas at Austin
- Lynn Morris
- Center for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS)
- Penny L. Moore
- Center for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS)
- Peter D. Kwong
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- John R. Mascola
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- George Georgiou
- Department of Chemical Engineering, The University of Texas at Austin
- DOI
- https://doi.org/10.1038/s41467-018-06424-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Knowledge on how antibody responses have evolved is critical for the induction of protective immunity. Here the authors analyse, using high-throughput sequencing of both exon and intron regions, the mutation and lineage development of an HIV-neutralizing antibody to find an unexpected early emergence of broadly neutralizing species.
