Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β

Xi Yang; Sourav Saha; Wei Yang; Keir C. Neuman; Yves Pommier

doi:10.1038/s41467-022-32221-3

Nature Communications (Aug 2022)

Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β

Xi Yang,
Sourav Saha,
Wei Yang,
Keir C. Neuman,
Yves Pommier

Affiliations

Xi Yang: Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH
Sourav Saha: Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH
Wei Yang: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Keir C. Neuman: Laboratory of Single Molecule Biophysics, National Heart, Lung and Blood Institute, National Institutes of Health
Yves Pommier: Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH

DOI: https://doi.org/10.1038/s41467-022-32221-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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The authors revealed novel roles of catalytic residues and divalent metal ions for hsTOP3B, the human RNA topoisomerase, and demonstrated the structural elements that kinetically modulate the DNA and RNA topoisomerase activities of TOP3B.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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